کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3049273 | 1579727 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The genetic architecture of autism and related disorders
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
مغز و اعصاب بالینی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Epidemiological twin studies demonstrate that autism spectrum disorders (ASDs) represent genetic disorders. Subsequent analyses indicate that the causes of ASDs include rarer single gene mutations and chromosomal abnormalities, as well as ASDs caused by multiple interacting genes of weak effect. Genome-wide linkage analysis has identified several susceptibility loci for the ASDs, and positional and functional candidate genes have been identified that may represent susceptibility genes for the ASDs. Analysis of additional larger samples, and the use of genome-wide association and high-throughput variant detection will lead to the identification of further genes for ASDs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neuroscience Research - Volume 6, Issues 3–4, October 2006, Pages 161–168
Journal: Clinical Neuroscience Research - Volume 6, Issues 3–4, October 2006, Pages 161–168
نویسندگان
D.E. Grice, J.D. Buxbaum,