کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3050771 1185963 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cognitive/behavioral teratogenetic effects of antiepileptic drugs
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Cognitive/behavioral teratogenetic effects of antiepileptic drugs
چکیده انگلیسی

The majority of children of mothers with epilepsy are normal, but they are at increased risk for developmental delay. Antiepileptic drugs (AEDs) appear to play a role. Our current knowledge is reviewed, including research design issues and recommendations for future research. In animals, exposure of the immature brain to some AEDs can produce widespread neuronal apoptosis and behavioral deficits. The risks of AEDs in humans are less clear, but recent studies raise concerns, especially for valproate. There is a critical need for well-designed systematic research to improve our understanding of AED effects on the fetal brain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 11, Issue 3, November 2007, Pages 292–302
نویسندگان
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