کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3069361 1580646 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: A speculative synthesis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: A speculative synthesis
چکیده انگلیسی

Parkinson's disease (PD) is mainly attributed to degeneration of dopamine neurons in the substantia nigra, but its etiopathogenesis also includes impaired protein clearance and axonal transport dysfunction, among others. The spread of α-synuclein (α-syn) aggregates from one neuron to another, in a prion-like manner, is hypothesized to contribute to PD progression. Axonal transport is likely to play a crucial role in this movement of α-syn aggregates between brain regions. At the same time, deficits in axonal transport are suggested to contribute to neuronal failure in PD. In this review, we discuss the apparent contradiction that axonal transport might be essential for disease progression, while dysfunction of axonal transport could simultaneously be a cornerstone of PD pathogenesis. We speculate around models that reconcile how axonal transport can play such a paradoxical role.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 77, May 2015, Pages 276–283
نویسندگان
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