کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3069616 1580698 2011 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in mice
چکیده انگلیسی

Current experimental models of blast injuries used to study blast-induced neurotrauma (BINT) vary widely, which makes the comparison of the experimental results extremely challenging. Most of the blast injury models replicate the ideal Friedländer type of blast wave, without the capability to generate blast signatures with multiple shock fronts and refraction waves as seen in real-life conditions; this significantly reduces their clinical and military relevance. Here, we describe the pathophysiological consequences of graded blast injuries and BINT generated by a newly developed, highly controlled, and reproducible model using a modular, multi-chamber shock tube capable of tailoring pressure wave signatures and reproducing complex shock wave signatures seen in theater. While functional deficits due to blast exposure represent the principal health problem for today's warfighters, the majority of available blast models induces tissue destruction rather than mimic functional deficits. Thus, the main goal of our model is to reliably reproduce long-term neurological impairments caused by blast. Physiological parameters, functional (motor, cognitive, and behavioral) outcomes, and underlying molecular mechanisms involved in inflammation measured in the brain over the 30 day post-blast period showed this model is capable of reproducing major neurological changes of clinical BINT.

Figure optionsDownload as PowerPoint slideResearch highlights
► The model mimics physiological and functional changes seen in soldiers after blast.
► The newly designed shock tube is able to reproduce military relevant scenarios.
► Inflammation in the brain may contribute to neurological deficits after blast.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 41, Issue 2, February 2011, Pages 538–551
نویسندگان
, , , , , , , , , ,