کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3070375 | 1580721 | 2009 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments](/preview/png/3070375.png)
In this study we analyzed the effect on behavior of a chronic exposure to brain-derived neurotrophic factor (BDNF), by analysing a mouse line overexpressing BDNF under the αCaMKII promoter, which drives the transgene expression exclusively to principal neurons of the forebrain. BDNF transgenic mice and their WT littermates were examined with a battery of behavioral tests, in order to evaluate motor coordination, learning, short and long-term memory formation. Our results demonstrate that chronic BDNF overexpression in the central nervous system (CNS) causes learning deficits and short-term memory impairments, both in spatial and instrumental learning tasks. This observation suggests that a widespread increase in BDNF in forebrain networks may result in adverse effects on learning and memory formation.
Journal: Neurobiology of Disease - Volume 33, Issue 3, March 2009, Pages 358–368