کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3070431 1580725 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short- and long-term limbic abnormalities after experimental febrile seizures
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Short- and long-term limbic abnormalities after experimental febrile seizures
چکیده انگلیسی

Experimental febrile seizures (FS) are known to promote hyperexcitability of the limbic system and increase the risk for eventual temporal lobe epilepsy (TLE). Early markers of accompanying microstructural and metabolic changes may be provided by in vivo serial MRI.FS were induced in 9-day old rats by hyperthermia. Quantitative multimodal MRI was applied 24 h and  8 weeks later, in rats with FS and age-matched controls, and comprised hippocampal volumetry and proton spectroscopy, and cerebral T2 relaxometry and diffusion tensor imaging (DTI). At 9 weeks histology was performed.Hippocampal T2 relaxation time elevations appeared to be transient. DTI abnormalities detected in the amygdala persisted up to 8 weeks. Hippocampal volumes were not affected. Histology showed increased fiber density and anisotropy in the hippocampus, and reduced neuronal surface area in the amygdala.Quantitative serial MRI is able to detect transient, and most importantly, long-term FS-induced changes that reflect microstructural alterations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 32, Issue 2, November 2008, Pages 293–301
نویسندگان
, , , , , , , , , ,