کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3070724 1580753 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice
چکیده انگلیسی

The brain levels of the endogenous excitotoxin quinolinic acid (QUIN) and its bioprecursor, the free radical generator 3-hydroxykynurenine (3-HK), are elevated in early stage Huntington disease (HD). We now examined the status of these metabolites in three mouse models of HD. In R6/2 mice, 3-HK levels were significantly and selectively elevated in the striatum, cortex and cerebellum starting at 4 weeks of age. In contrast, both 3-HK and QUIN levels were increased in the striatum and cortex of the full-length HD models, beginning at 8 months (YAC128) and 15 months (HdhQ92 and HdhQ111), respectively. No changes were seen in 13-month-old shortstop mice, which show no signs of motor or cognitive dysfunction or selective neuropathology. These results demonstrate both important parallels and intriguing differences in the progressive neurochemical changes in these HD mouse models and support the hypothesis that QUIN may play a role in the striatal and cortical neurodegeneration of HD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 23, Issue 1, July 2006, Pages 190–197
نویسندگان
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