کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3088666 1581318 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Émotion et noyaux gris centraux (II) : que peut-nous apprendre le modèle de la stimulation cérébrale profonde du noyau subthalamique dans la maladie de Parkinson ?
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Émotion et noyaux gris centraux (II) : que peut-nous apprendre le modèle de la stimulation cérébrale profonde du noyau subthalamique dans la maladie de Parkinson ?
چکیده انگلیسی
The subthalamic nucleus deep-brain stimulation Parkinson's disease patient model seems to represent a unique opportunity for studying the functional role of the basal ganglia and notably the subthalamic nucleus in human emotional processing. Indeed, in addition to constituting a therapeutic advance for severely disabled Parkinson's disease patients, deep brain stimulation is a technique, which selectively modulates the activity of focal structures targeted by surgery. There is growing evidence of a link between emotional impairments and deep-brain stimulation of the subthalamic nucleus. In this context, according to the definition of emotional processing exposed in the companion paper available in this issue, the aim of the present review will consist in providing a synopsis of the studies that investigated the emotional disturbances observed in subthalamic nucleus deep brain stimulation Parkinson's disease patients. This review leads to the conclusion that several emotional components would be disrupted after subthalamic nucleus deep brain stimulation in Parkinson's disease: subjective feeling, neurophysiological activation, and motor expression. Finally, after a description of the limitations of this study model, we discuss the functional role of the subthalamic nucleus (and the striato-thalamo-cortical circuits in which it is involved) in emotional processing. It seems reasonable to conclude that the striato-thalamo-cortical circuits are indeed involved in emotional processing and that the subthalamic nucleus plays a central in role the human emotional architecture.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue Neurologique - Volume 168, Issues 8–9, August–September 2012, Pages 642-648
نویسندگان
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