کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3090209 1190257 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effets à long terme de la chimiothérapie chez 7 patients présentant un gliome de bas grade symptomatique
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Effets à long terme de la chimiothérapie chez 7 patients présentant un gliome de bas grade symptomatique
چکیده انگلیسی
Whether aggressive treatment or no treatment is the optimal management for low-grade gliomas is controversial. However, symptomatic low-grade gliomas require prompt therapeutic intervention because of neurological impairment, uncontrolled seizures, and deterioration of life quality. Methods. We report the long-term follow-up, 71 months, of seven patients treated by procarbazine, lomustine and vincristine (PCV) therapy for a symptomatic low-grade oligodendrogliomatous tumor. The mean age at diagnosis was 47 years, the mean time from first symptoms to initiation of PCV therapy was 62 months (range 15-147). Results. All patients initially responded favorably, with improvement of the neurological symptoms and radiological response. Chemotherapy was clinically well tolerated, the main side effect being low hematological toxicity. During the follow-up, no progression was observed in two patients. For the five remaining patients, the time to progression after the PCV induction was 56±12 months (range 38 to 73). Four of these patients showed favorable response to a second line of treatment. Conclusion. PCV therapy is an interesting therapeutic option for progressively symptomatic low-grade gliomas, even in cases with large tumoral volume. This treatment, of moderate toxicity, improves the quality of life and can result in long-term tumor stabilization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue Neurologique - Volume 162, Issue 11, November 2006, Pages 1069-1075
نویسندگان
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