Rôle de l'immunité dans le développement de la leucoencéphalopathie multifocale progressive

Humoral immunosuppression in lymphoma can contribute to the development of PML PML prognosis is often severe but prolonged survivals were described. So it is necessary to restore a sufficient immunity level. But immunity failure may be insufficient to lead to PML. In the case of lymphomas, the role of malignant lymphocytes in multiplication and mutation of JCV might be an interesting pathophysiological hypothesis.