کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
31105 | 44544 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Specific interaction of jacalin with phycocyanin, a fluorescent phycobiliprotein
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Specific interaction of jacalin with phycocyanin, a fluorescent phycobiliprotein Specific interaction of jacalin with phycocyanin, a fluorescent phycobiliprotein](/preview/png/31105.png)
چکیده انگلیسی
Recent research has shown that, like porphyrins, phycocyanin (PC) too can produce singlet oxygen upon excitation with the appropriate radiation and hence could be useful in photodynamic therapy (PDT) for cancer. Unlike porphyrins, PC has the advantage of being a non-toxic, non-carcinogenic, soluble protein. However, the challenge would be to target the fluorescent phycobiliprotein to malignant cells. We report here that the tumor-specific lectin, jacalin, binds PC specifically in a carbohydrate-independent manner and with affinities better than that for porphyrins. Hence the lectin could prove to be a useful carrier for targeted delivery of PC. The interaction involves both ionic and hydrophobic interactions and more than one contact site.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 97, Issue 2, 9 November 2009, Pages 87–93
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 97, Issue 2, 9 November 2009, Pages 87–93
نویسندگان
Gunjan Pandey, Tasneem Fatma, Sudha M. Cowsik, Sneha Sudha Komath,