کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3120692 1583291 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of initial periodontal treatment on plasma, gingival crevicular fluid and salivary levels of 8-hydroxy-deoxyguanosine in obesity
ترجمه فارسی عنوان
تاثیر درمان اولیه پریودنتال بر پلاسما، مایع کرویوکولر لثه و سطوح بزاقی 8 هیدروکسی دگزیگوآگوسین در چاقی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی


• We analysed 8-OHdG levels in obese patients with periodontal disease after therapy.
• Plasma 8-OHdG levels in obese patients were higher than normal-weight individuals.
• Saliva and GCF 8-OHdG levels were so close for obese and normal-weight individuals.
• Plasma, saliva and GCF levels of 8-OHdG decreased after the therapy.
• Periodontal therapy had successful results for obese and normal-weight individuals.

ObjectiveRecent studies have shown adverse effects on the periodontium from the increased production of reactive oxygen species (ROS) in obesity. The purpose of this study was to investigate the effects of obesity on 8-hydroxy-deoxyguanosine (8-OHdG) levels in the bodily fluids of patients with and without periodontal disease and to evaluate changes after initial periodontal treatment.DesignForty-five obese individuals and 45 normal-weight individuals were included in this study. Obese and normal-weight groups were classified into three sub-groups: chronic periodontitis (CP), gingivitis (G) and periodontally healthy controls (CTRL). Gingival crevicular fluid (GCF), plasma, saliva samples and clinical measurements were obtained at baseline and a month after initial periodontal treatment. Levels of 8-OHdG were analysed by ELISA.ResultsWhile plasma 8-OHdG levels were significantly higher at baseline in the obese patients with periodontal disease than in the normal-weight individuals (P < 0.05), no significant differences in GCF and saliva 8-OHdG levels were found (P ˃ 0.05). GCF and salivary 8-OHdG levels in obese patients with G and CP were significantly higher than in CTRL groups at baseline (P < 0.05). After treatment, 8-OHdG levels were decreased in all groups with periodontal disease (P < 0.01). Statistically significant positive correlations were observed between GCF 8-OHdG levels and GI in all the groups (P < 0.001).ConclusionsThe significant increase of plasma 8-OHdG levels in obese patients did not correlate with saliva and GCF 8-OHdG levels when compared to normal-weight individuals. Periodontal treatment had a positive effect on the periodontal parameters and 8-OHdG levels of both obese and normal-weight individuals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 62, February 2016, Pages 80–85
نویسندگان
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