کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3163920 1198754 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Elective versus therapeutic neck dissection in node-negative oral cancer: Evidence from five randomized controlled trials
ترجمه فارسی عنوان
تشخیص قطعی گردن درمانی در سرطان دهان گره منفی: شواهدی از پنج کارآزمایی بالینی تصادفی شده است
کلمات کلیدی
متاآنالیز، محصور گردن انتخابی، نظارت، درمان دیسک گردن، آزمایش تصادفی کنترل شده
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی


• This study may provide paramount evidence for surgeons to make treatment plan of OSCC.
• All the included studies are RCTS.
• This study’s sample size is probably the largest by now.

SummaryThe aim of this study was to compare the outcomes of elective neck dissection (END) with that of a more conservative approach comprising of observation plus therapeutic neck dissection for nodal relapse (OBS), by conducting a meta-analysis of randomized controlled trials (RCTs) that compare these two surgical approaches in patients. RCTs conducted prior to May 2015 were identified from electronic databases such as MEDLINE EMBASE and Cochrane Library. Reference lists within the retrieved articles were used as secondary reference sources. Disease-free survival (DFS) and overall survival (OS) were the primary outcome measures. Five RCTs with a combined subject population of 779 patients were included. Meta-analysis of these 5 RCTs showed that DFS in END group was higher than that in the OBS group with a significant inter-group difference (Risk Ratio [RR]:1.33; 95% Confidence Interval [CI] 1.06, 1.66); P = 0.01; five trials, 779 participants]. However, there was a significant statistical heterogeneity among the studies (I-squared = 56%, P = 0.06). Four studies had reported on OS. Meta-analysis of these 4 RCTs revealed a higher OS in the END group as compared to that that in the OBS group with a significant inter-group difference (RR: 1.18; 95% CI 1.07, 1.29); P = 0.0009; four trials, 708 participants]. The statistical heterogeneity of these 4 studies is small (I-squared = 14%, P = 0.32). The results of this meta-analysis suggest that END at the time of resection of the primary tumor confers a DFS and OS benefit in patients with clinically node-negative oral cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 51, Issue 11, November 2015, Pages 976–981
نویسندگان
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