کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3164667 1198804 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CCR2-64I gene polymorphism increase susceptibility to oral cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
CCR2-64I gene polymorphism increase susceptibility to oral cancer
چکیده انگلیسی

SummaryThe purpose of this study was to investigate the impact of MCP-1 and its receptor CCR2 gene polymorphisms on the susceptibility and clinicopathological characteristics of oral cancer, as well as the synergistic effect between these gene polymorphisms and well-known risk factors including alcohol, tobacco, and areca consumptions. Using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) technique for polymorphism analysis, 344 healthy controls and 216 oral cancer patients were recruited to reveal a significant association between V64I CCR2 gene polymorphism and oral cancer susceptibility. After adjusting for other confounders, individuals with GA (AOR = 1.84; 95%CI = 1.10–3.20) or at least one A allele (AOR = 1.78; 95%CI = 1.05–3.02) had a higher risk for oral cancer, compared to GG genotypes. Moreover, results also revealed that for subjects with GA or at least one A allele of V64I CCR2 gene polymorphism, those exposed to environmental risk factors possessed a significantly higher risk for oral cancer than those unexposed subjects. Therefore, genetic polymorphism of CCR2-64I may contribute to the susceptibility to oral cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 47, Issue 7, July 2011, Pages 577–582
نویسندگان
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