کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3165582 | 1198841 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD4+ T helper responses in squamous cell carcinoma of the head and neck
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کلمات کلیدی
IVST helper type 1In vitro stimulationEBV-BT helper type 2MLTCProstaglandin E-2PGE-2SCCHNTh2Th1PBLsMitomycin Cphorbol 12-myristate 13-acetateTGFPBMCsDCsmAbFBSp53MMCCTLs - CTL هاPMA - LDC هاMonoclonal antibody - آنتی بادی مونوکلونالhuman leukocyte antigens - آنتی ژن های لکوستیک انسانیtumor-associated antigens - آنتی ژن های مرتبط با تومورHLA - آنتیژن گلبول سفید انسانیinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینtransforming growth factor - تبدیل فاکتور رشدTumor-infiltrating lymphocytes - تومور لنفوسیتها نفوذ می کندTILS - جریان بداخلTAAs - دوبارهfetal bovine serum - سرم جنین گاوperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیDendritic cells - سلول های دندریتیکCD4+ T cells - سلولهای CD4 + TCytotoxic T lymphocytes - لنفوسیت های T سیتوتوکسیکperipheral blood lymphocytes - لنفوسیت های خون محیطیmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیMHC - مجموعه سازگاری بافتی اصلیwild type - نوع وحشیSquamous cell carcinoma of the head and neck - کارسینوم سلول سنگفرشی سر و گردنcomplete medium - کامل رسانه
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
دندانپزشکی، جراحی دهان و پزشکی
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چکیده انگلیسی
Anti-tumor immunity plays an important role in the development of and protection from malignancy. However, there is a lack of information regarding induction of CD4+ T helper responses in patients with squamous cell carcinoma (SCCHN). To explore anti-tumor immune responses against SCCHN, a permanent cell line, Gun-1 was established from a squamous cell carcinoma of the hypopharynx. In addition to its characterization, we performed mixed lymphocyte-tumor cell cultures (MLTC) using peripheral blood lymphocytes and autologous tumor cells. Furthermore, T cell responses to wild type (wt) p53-derived peptides were assessed. Gun-1 cells overexpressed p53 and were negative for HLA-A2 expression. No tumor-specific or wt p53-specific CD8+ CTL lines could be established from peripheral blood mononuclear cells (PBMCs) of this patient. Autologous tumor-specific HLA-DR-restricted CD4+ T helper clone was obtained by limiting dilutions using bulk populations from MLTC. This clone produced IFN-γ but not IL-5 in response to autologous tumor cells. In addition, CD4+ T cells were generated from the patient's PBMCs which responded to two HLA-DP5-restricted wt p53-derived peptides. Our results suggest that the immune cells specific for autologous tumor as well as wt p53-derived epitopes are present in the peripheral circulation of this cancer patient. However, helper-type CD4+ T lymphocytes represent the predominant anti-tumor response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 44, Issue 9, September 2008, Pages 870-877
Journal: Oral Oncology - Volume 44, Issue 9, September 2008, Pages 870-877
نویسندگان
Kazuaki Chikamatsu, Koichi Sakakura, Takanori Yamamoto, Nobuhiko Furuya, Theresa L. Whiteside, Keisuke Masuyama,