Clinical correlates of enlarged cavum septum pellucidum in schizophrenia: A revisit through computed tomography

• Clinical correlates of enlarged cavum septum pellucidum in schizophrenia were examined.
• Two groups of patients with and without enlarged cavum septum pellucidum were compared.
• Current age and duration of illness was significantly higher in patients with enlarged cavum septum pellucidum.
• Sociodemographic variables and clinical symptomatology were comparable in both groups.
• Enlarged cavum septum pellucidum dimensions did not correlate with any clinical factors.

Like prevalence of abnormal cavum septum pellucidum in patients of schizophrenia remains controversial, its role in clinical outcome, duration of illness and effect on treatment remains less understood as well. Our study examined clinical correlates of enlarged cavum septum pellucidum in schizophrenia. A total of 139 patients diagnosed with schizophrenia during the year 2012 and 2013 were taken for the study. We compared them in respect to the presence and absence of enlarged cavum septum pellucidum. We found 16 patients with enlarged cavum septum pellucidum and were compared with those without enlarged cavum septum pellucidum for socio-demographic and clinical variables. We also correlated these clinical variables with dimension of cavum septum pellucidum. We found statistically significant increased current age and duration of illness in patients with enlarged cavum septum pellucidum. The implications of these findings are discussed with possible confounding effect of current age on neuroimaging. No meaningful correlation was found. No difference in clinical variables was found. Retrospective design and use of computed tomography were limitation of our study.