In vivo Precision of the GE Lunar iDXA Densitometer for the Measurement of Total-Body, Lumbar Spine, and Femoral Bone Mineral Density in Adults

Knowledge of precision is integral to the monitoring of bone mineral density (BMD) changes using dual-energy X-ray absorptiometry (DXA). We evaluated the precision for bone measurements acquired using a GE Lunar iDXA (GE Healthcare, Waukesha, WI) in self-selected men and women, with mean age of 34.8 yr (standard deviation [SD]: 8.4; range: 20.1-50.5), heterogeneous in terms of body mass index (mean: 25.8 kg/m2; SD: 5.1; range: 16.7-42.7 kg/m2). Two consecutive iDXA scans (with repositioning) of the total body, lumbar spine, and femur were conducted within 1 h, for each subject. The coefficient of variation (CV), the root-mean-square (RMS) averages of SDs of repeated measurements, and the corresponding 95% least significant change were calculated. Linear regression analyses were also undertaken. We found a high level of precision for BMD measurements, particularly for scans of the total body, lumbar spine, and total hip (RMS: 0.007, 0.004, and 0.007 g/cm2; CV: 0.63%, 0.41%, and 0.53%, respectively). Precision error for the femoral neck was higher but still represented good reproducibility (RMS: 0.014 g/cm2; CV: 1.36%). There were associations between body size and total-body BMD and total-hip BMD SD precisions (r = 0.534-0.806, p < 0.05) in male subjects. Regression parameters showed good association between consecutive measurements for all body sites (r2 = 0.98-0.99). The Lunar iDXA provided excellent precision for BMD measurements of the total body, lumbar spine, femoral neck, and total hip.