کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3271699 | 1208276 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of Precision Error on T-scores and the Diagnostic Classification of Bone Status
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
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چکیده انگلیسی
We quantified confidence intervals (CIs) for T-scores for the lumbar spine and hip and determined the practical effect (impact on diagnosis) of variability around the T-score cutpoint of â2.5. Using precision data from the literature for GE Lunar Prodigy dual-energy X-ray absorptiometry (DXA) systems, the 95% CI for the T-score was ±0.23 at the lumbar spine (L1-L4), ± 0.20 at the total hip, and ±0.41 at the femoral neck. Thus, T-score variations of ±0.23 or less at the spine, ±0.20 at the total hip, and ±0.41 at the femoral neck are not statistically significant. When diagnosing osteoporosis, T-scores in the interval â2.3 to â2.7 for spine or total hip (after rounding to conform to guidelines from the International Society for Clinical Densitometry) and â2.1 to â2.9 for femoral neck are not statistically different from â2.5. Better precision values resulted in smaller 95% CIs. This concept was applied to actual clinical data using Hologic DXA systems. The study cohort comprised 2388 white women with either normal or osteopenic spines in whom the densitometric diagnosis of osteoporosis would be determined by hip T-scores. When evaluating actual patient T-scores in the range â2.5 ± 95% CI, we found that the diagnosis was indeterminate in approximately 12% of women when T-scores for femoral neck were used and in 4% of women when T-scores for total hip were used, with uncertainty as to whether the classification was osteopenia or osteoporosis. We conclude that precision influences the variability around T-scores and that this variability affects the reliability of diagnostic classification.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Densitometry - Volume 10, Issue 3, JulyâSeptember 2007, Pages 239-243
Journal: Journal of Clinical Densitometry - Volume 10, Issue 3, JulyâSeptember 2007, Pages 239-243
نویسندگان
Gary M. Kiebzak, Kenneth G. Faulkner, Wynn Wacker, Ronald Hamdy, Edith Seier, Nelson B. Watts,