کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3283792 | 1209186 | 2009 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Proton Pump Inhibitors for Gastroduodenal Damage Related to Nonsteroidal Anti-inflammatory Drugs or Aspirin: Twelve Important Questions for Clinical Practice
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کلمات کلیدی
COXRRRNSAIDH2RAPPIPUBGPARCTRandomized controlled trial - آزمایش تصادفی کنترل شدهLow-dose aspirin - آسپرین با دوز کمH2-receptor antagonist - آنتاگونیست گیرنده H2cyclooxygenase - آنزیم سیکلواکسیژنازLDA - تخصیص پنهان دیریکلهRelative risk - خطر نسبیpeptic ulcer bleeding - خونریزی زخم معدهnonsteroidal anti-inflammatory drug - داروهای ضد التهابی غیر استروئیدیGastrointestinal - دستگاه گوارشconfidence interval - فاصله اطمینانProton pump inhibitor - مهار کننده پمپ پروتونodds ratio - نسبت شانس هاrelative risk reduction - کاهش خطر نسبی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin are among the most commonly used medications worldwide. Their use is associated with significant gastroduodenal adverse effects, including dyspepsia, bleeding, ulcer formation, and perforation. Given their long-term use by millions of patients, there is a substantial impact at the population level of these complications. In this evidence-based review, we have endeavored to answer 12 commonly encountered questions in clinical practice that deal with the following: extent of the problem of NSAID/aspirin-induced gastroduodenal damage and its impact on public health; role of proton pump inhibitors (PPIs) in the primary prevention, healing, and secondary prevention of NSAID/aspirin-induced gastroduodenal ulceration as assessed by using endoscopic end points; role of PPIs in the prevention of adverse clinical outcomes related to NSAID/aspirin use; whether PPIs are effective in NSAID-induced dyspepsia; comparison of PPI co-therapy with selective cyclooxygenase-2 inhibitors for risk reduction of adverse clinical outcomes; role of PPIs in preventing rebleeding from aspirin ± clopidogrel therapy in high-risk patients; identifying high-risk patients who can benefit from PPI co-therapy; the role of other gastroprotective agents for prevention of NSAID/aspirin-induced gastroduodenal damage; and the cost-effectiveness of and limitations to the use of PPIs for prevention of gastroduodenal damage related to the use of NSAIDs or aspirin. We then summarized our recommendations on the use of PPIs for the clinical management of patients using NSAIDs or aspirin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 7, Issue 7, July 2009, Pages 725-735.e4
Journal: Clinical Gastroenterology and Hepatology - Volume 7, Issue 7, July 2009, Pages 725-735.e4
نویسندگان
Gaurav Arora, Gurkirpal Singh, George Triadafilopoulos,