کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3328326 | 1212307 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
WpÅyw cytotoksyczny R-amfinazy, endorybonukleazy o dziaÅaniu przeciwnowotworowym, na komórki chÅoniaka rozlanego z dużych komórek B w warunkach in vitro
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: WpÅyw cytotoksyczny R-amfinazy, endorybonukleazy o dziaÅaniu przeciwnowotworowym, na komórki chÅoniaka rozlanego z dużych komórek B w warunkach in vitro WpÅyw cytotoksyczny R-amfinazy, endorybonukleazy o dziaÅaniu przeciwnowotworowym, na komórki chÅoniaka rozlanego z dużych komórek B w warunkach in vitro](/preview/png/3328326.png)
چکیده انگلیسی
Onconase (ONC) and R-Amphinase (R-AM) are enzymes with anti-tumor activity, belonging to pancreatic ribonuclease A family, received from eggs collected from frog Rana pipiens. Both proteins can induce death of some types of neoplastic cells by inhibition of protein synthesis, cell growth and proliferation. The aim of this study was to assess the cytotoxicity of R-AM, used alone or in combination with one of the most active anti-leukemic drug, doxorubicin (DOX), on diffuse large B-cell lymphoma (DLBCL)-derived cell line, Toledo. We found high cytotoxic activity of R-AM against DLBCL cells as well as influence on expression of several apoptosis-regulating proteins. Moreover, we observed increase in proapoptotic activity after combination of R-AM and DOX, compared with both drugs used alone. These results may justify further studies on interactions of R-AM with other drugs active in DLBCL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Haematologica Polonica - Volume 45, Issue 1, JanuaryâMarch 2014, Pages 62-68
Journal: Acta Haematologica Polonica - Volume 45, Issue 1, JanuaryâMarch 2014, Pages 62-68
نویسندگان
MaÅgorzata ZwoliÅska, Barbara Cebula-Obrzut, Magdalena Witkowska, Agata Majchrzak, Aleksandra MÄdra, Piotr Smolewski,