کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3328921 | 1212362 | 2012 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Anti-leukemic properties of IL-12, IL-23 and IL-27: Differences and similarities in the control of pediatric B acute lymphoblastic leukemia Anti-leukemic properties of IL-12, IL-23 and IL-27: Differences and similarities in the control of pediatric B acute lymphoblastic leukemia](/preview/png/3328921.png)
B acute lymphoblastic leukemia (ALL) is the most common pediatric hematologic malignancy. Although patient cure has reached an excellent rate, a minority of cases relapse and need novel therapies.IL-12, IL-23 and IL-27 belong to the IL-12 superfamily and exert immunological and anti-tumor functions. The latter can be mediated by activation of immune responses or by the direct activity on cancer cells. Recently, the role of IL-12, IL-23 and IL-27 in the control of pediatric B-ALL has been unveiled. Here, we discuss in a translational perspective the role of IL-12 family cytokines in pediatric B-ALL, highlighting similarities and differences in their mechanisms of action.
► We review and discuss the role of IL-12, IL-23 and IL-27 in pediatric B-ALL.
► The cytokines show direct anti-leukemic activity with similar and different mechanisms.
► IL-27 is able to target both B-ALL blasts and TIC and inhibits their spreading in vivo.
► IL-27 appears as a good candidate for B-ALL therapy due to its multifaceted activity.
Journal: Critical Reviews in Oncology/Hematology - Volume 83, Issue 3, September 2012, Pages 310–318