| کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
|---|---|---|---|---|
| 3336457 | 1213605 | 2016 | 7 صفحه PDF | دانلود رایگان |
کلیدواژه ها
روش ها
استراتژی جستجو
انتخاب مطالعه و استخراج داده
شکل 1. فلوچارتی که فرآیند طراحی مطالعه را شرح می دهد.
جدول 1. ویژگی های خط مبنای مطالعات گنجانده شده بر اساس مناطق جغرافیایی
شکل 2. طرح قیفی برای جهت انتشار مستقیم
تحلیل متا
جدول 2. تحلیل زیرگروه برای مقایسه شیوع در قاره های مختلف
نتایج
شکل 3. نمودار طرح جنگلی شیوع گزارش شده از پادتن ها به تی گوندی.
شکل 4. شیوع کل پادتن ها به تی گوندی در اهدا کنندگان خون از مکان های جغرافیایی مختلف.
بحث
شکل 5. طرح رگرسیون متا از پادت ها به تی گوندی با توجه به سال مطالعه.
شکل 6. طرح رگرسیون متا از پادتن ها به تی گوندی با توجه به اندازه نمونه مطالعه.
جدول 3. عوامل ریسک مرتبط با شیوع سرمی برای تی گوندی در اهدا کنندگان خون
جدول 4. اپیدمولوژی مولکوی عفونت توکسوپلاسما در اهدا کنندگان خون
شرح تضاد منافع
• Toxoplasmosis is considered as a neglected transfusion-transmitted disease.
• We conducted a global systematic review and meta-analysis to assess the prevalence of toxoplasmosis in blood supplies and blood donors.
• The overall weighted prevalence of toxoplasmosis in blood donors was determined to be 33% (95% CI, 28%-39%).
• Although a relatively high prevalence was reached in our results, this finding is not necessarily representative of active infection and this does not lead to a conclusion that blood donation screening is required.
Transfusion-transmissible infections include pathogens that may cause severe and debilitating diseases. Toxoplasmosis is a cosmopolitan neglected parasitic infection that can lead to severe complications including death in immune-compromised patients or following infection in utero. Multiple studies have demonstrated the transmission of Toxoplasma gondii by blood transfusion. The objective of this review was to comprehensively assess the seroprevalence rate of Toxoplasma in blood donors from a worldwide perspective. Seven electronic databases (PubMed, Science Direct, Web of Science, Scopus, Cochrane, Ovid, and Google Scholar) were searched using medical subject headings terms. A total of 43 records met the inclusion criteria in which 20,964 donors were tested during the period from January 1980 to June 2015. The overall weighted prevalence of exposure to toxoplasmosis in blood donors was 33% (95% confidence interval [CI], 28%-39%). The seroprevalences of immunoglobulin (Ig)M and both IgG and IgM antibodies were 1.8% (95% CI, 1.1%-2.4%) and 1.1% (95% CI, 0.3%-1.8%), respectively. The highest and the lowest seroprevalences of toxoplasmosis were observed in Africa (46%; 95% CI, 14%-78%) and in Asia (29%; 95% CI, 23%-35%), respectively. Brazil (75%) and Ethiopia (73%) were identified as countries with high seroprevalence. Because positive serology does not imply infectiousness and because seroprevalence is high in some nations, a positive serology test result alone cannot be used as an effective method for donor screening. Future research for methods to prevent transfusion-transmitted toxoplasmosis may derive benefit from studies conducted in areas of high endemicity.
Journal: Transfusion Medicine Reviews - Volume 30, Issue 3, July 2016, Pages 116–122