کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3355536 | 1217189 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Regulatory T cells, dendritic cells and neutrophils in patients with renal cell carcinoma Regulatory T cells, dendritic cells and neutrophils in patients with renal cell carcinoma](/preview/png/3355536.png)
• Patients with renal cell carcinoma have more dendritic cells in the blood than controls.
• Percentage of plasmacytoid dendritic cells in tumors is higher in the early stages.
• Neutrophils comprise bigger portion of tumor infiltrating leukocytes in the late stages.
• Patients with renal cancer have more regulatory T lymphocytes in the blood than healthy controls.
• Regulatory T lymphocytes accumulate in tumor tissue regardless the disease stage.
We evaluated dendritic cells (DC), regulatory T lymphocytes (Treg) and neutrophils in 37 patients with newly diagnosed renal cell carcinoma (RCC) in the tumor and peripheral blood (PB) and correlated these parameters with tumor staging (early-T1, 2, late-T3, 4 and metastatic disease). The number of myeloid and plasmacytoid DC in blood of RCC patients was higher than in healthy controls. The percentage of myeloid dendritic cells (mDC) from CD45+ cells in tumors was higher in comparison with peripheral blood irrespective of disease stage. Higher percentage of these cells expressed a maturation marker in the periphery in the early stage (CD83 expressing cells). The number of plasmacytoid dendritic cells (pDC) in PB was similar in both early and late stage groups, but the early group displayed a significantly higher percentage of pDC in tumor cell suspension. Neutrophil counts in the peripheral blood of RCC patients were higher than in healthy controls, but the counts in both tumor stage groups were similar. The proportion of neutrophils from CD45+ cells was higher in late stage tumors. Higher percentage of Treg from CD4+ cells was detected in renal carcinoma tissue in comparison to PB with no difference between stages of the disease. Our results reflect the complex interplay between various cells of the immune system and the tumor microenvironment. Activation of dendritic cell subpopulations at early stages of the disease course is counterbalanced by the early appearance of T regulatory cells both in the periphery and tumor tissue. Later stages are characterized by the accumulation of neutrophils in the tumor. Appropriate timing of anticancer strategies, especially immunotherapy, should take these dynamics of the immune response in RCC patients into account.
Journal: Immunology Letters - Volume 152, Issue 2, May 2013, Pages 144–150