Dissection of inflammatory processes using chemokine biology: Lessons from clinical models

Chemokines help facilitate the recruitment of inflammatory cells into tissues in response to infection or inflammation, and help coordinate the actions of the leukocytes that underlie an immune response. Animal models are the experimental tools of choice for the validation of chemokine biology and have provided much insight into the workings of chemokine biology. This review summarizes findings from chemokine research obtained through the application of animal models of pulmonary fibrosis, graft-versus-host disease, colitis, renal disease and allograft rejection.

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► Chemokine biology is complex.
► It underlies the induction and propagation of inflammatory and autoimmune disease.
► Diverse strategies have been applied to evaluate chemokine biology in vivo.
► Functionally relevant therapeutic targets have been identified.
► Future steps will involve testing bioactive chemokine reagents in humans.