کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3368359 | 1218785 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The development of targeted therapies in rheumatoid arthritis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The therapy of rheumatoid arthritis has been revolutionised by advances in the understanding of disease at a cellular and molecular level accompanied by the technology to target specific mediators of disease. Proposed therapeutic targets from in vitro and animal models however have frequently resulted in unexpected outcomes in clinical trials. These have included have included cytokines, chemokines, the T cell receptor trimolecular complex, T cells and B cells. The most successful strategies have resulted from a close dialogue between clinical and laboratory work. The key stages in the development of these agents and remaining unanswered questions are reviewed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 31, Issue 3, November 2008, Pages 219-227
Journal: Journal of Autoimmunity - Volume 31, Issue 3, November 2008, Pages 219-227
نویسندگان
Edward M. Vital, Paul Emery,