کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
338461 547954 2010 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Disorganization and reality distortion in schizophrenia: A meta-analysis of the relationship between positive symptoms and neurocognitive deficits
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Disorganization and reality distortion in schizophrenia: A meta-analysis of the relationship between positive symptoms and neurocognitive deficits
چکیده انگلیسی

BackgroundFactor analytic studies have shown that in schizophrenia patients, disorganization (e.g., conceptual disorganization and bizarre behavior) is a separate dimension from other types of positive symptoms such as reality distortion (delusions and hallucinations). Although some studies have found that disorganization is more strongly linked to neurocognitive deficits and poor functional outcomes than reality distortion, the findings are not always consistent.MethodsA meta-analysis of 104 studies (combined n = 8015) was conducted to determine the magnitude of the relationship between neurocognition and disorganization as compared to reality distortion. Additional analyses were conducted to determine whether the strength of these relationships differed depending on the neurocognitive domain under investigation.ResultsThe relationship between reality distortion and neurocognition was weak (r = −.04; p = .03) as compared to the moderate association between disorganization and neurocognition (r = −.23; p < .01). In each of the six neurocognitive domains that were examined, disorganization was more strongly related to neurocognition (r's range from −.20 to −.26) than to reality distortion (r's range from .01 to −.12).ConclusionsThe effect size of the relationship between neurocognition and disorganization was significantly larger than the effect size of the relationship between neurocognition and reality distortion. These results hold across several neurocognitive domains. These findings support a dimensional view of positive symptoms distinguishing disorganization from reality distortion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 121, Issues 1–3, August 2010, Pages 1–14
نویسندگان
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