کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391284 1221024 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complement therapeutic strategies in trauma, hemorrhagic shock and systemic inflammation – closing Pandora’s box?
ترجمه فارسی عنوان
استراتژی های درمانی تروما، شوک هموراژیک و التهاب سیستمیک مکمل؟ بستن جعبه پاندورا؟
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


• Severe tissue damage and activation of the coagulation system may trigger the complement cascade through established and non-canonical pathways.
• Severe tissue trauma and hemorrhagic shock leads to complement activation and complementopathy.
• Upstream inhibition of the complement cascade at the level of C3 may reduce trauma- and hemorrhagic shock-induced organ damage and improve overall outcome.
• Downstream specific blockade of the C5a-C5aR interaction may especially ameliorate septic conditions and complications following severe trauma and hemorrhagic shock.

After severe trauma, the immune system is challenged with a multitude of endogenous and exogenous danger molecules. The recognition of released danger patterns is one of the prime tasks of the innate immune system. In the last two decades, numerous studies have established the complement cascade as a major effector system that detects and processes such danger signals. Animal models with engineered deficiencies in certain complement proteins have demonstrated that widespread complement activation after severe injury culminates in complement dysregulation and excessive generation of complement activation fragments. Such exuberant pro-inflammatory signaling evokes systemic inflammation, causes increased susceptibility to infections and is associated with a detrimental course of the disease after injury. We discuss the underlying processes of such complementopathy and recapitulate different intervention strategies within the complement cascade. So far, several orthogonal anti-complement approaches have been tested with varying success in a large number of rodent, in several porcine and few simian studies. We illustrate the different features among those intervention strategies and highlight those that hold the greatest promise to become potential therapeutic options for the intricate disease of traumatic injury.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 28, Issue 3, June 2016, Pages 278–284
نویسندگان
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