کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391399 1221043 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Systems biological approaches to measure and understand vaccine immunity in humans
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Systems biological approaches to measure and understand vaccine immunity in humans
چکیده انگلیسی


• Recent studies have used systems biological approaches to predict vaccine efficacy.
• Such studies are yielding new insights about the mechanisms underlying vaccine immunity.
• Data acquisition, management and modeling represent major challenges.
• Integration of multiple “omics” data also represents major challenges.
• Overcoming such challenges will enable systems approaches to guide rational vaccine design.

Recent studies have demonstrated the utility of using systems approaches to identify molecular signatures that can be used to predict vaccine immunity in humans. Such approaches are now being used extensively in vaccinology, and are beginning to yield novel insights about the molecular networks driving vaccine immunity. In this review, we present a broad review of the methodologies involved in these studies, and discuss the promise and challenges involved in this emerging field of “systems vaccinology.”

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 25, Issue 3, 31 October 2013, Pages 209–218
نویسندگان
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