کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3391433 | 1221047 | 2012 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Age-related changes in CD8 T cell homeostasis and immunity to infection Age-related changes in CD8 T cell homeostasis and immunity to infection](/preview/png/3391433.png)
Studies of CD8 T cell responses to vaccination or infection with various pathogens in both animal models and human subjects have revealed a markedly consistent array of age-related defects. In general, recent work shows that aged CD8 T cell responses are decreased in magnitude, and show poor differentiation into effector cells, with a reduced arsenal of effector functions. Here we review potential mechanisms underlying these defects. We specifically address phenotypic and numeric changes to the naïve CD8 T cell precursor pool, the impact of persistent viral infection(s) and inflammation, and contributions of the aging environment in which these cells are activated.
► CD8 T cell responses become impaired in both magnitude and function as a consequence of age.
► Aging dramatically impacts naïve CD8 T cell precursors, both numerically and phenotypically.
► Extrinsic factors may further contribute to a decline in CD8 T priming efficacy in late life.
Journal: Seminars in Immunology - Volume 24, Issue 5, October 2012, Pages 356–364