کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391589 1221062 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Induction of Treg cells in the mouse colonic mucosa: A central mechanism to maintain host–microbiota homeostasis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Induction of Treg cells in the mouse colonic mucosa: A central mechanism to maintain host–microbiota homeostasis
چکیده انگلیسی

CD4+ regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a critical role in maintaining immunological homeostasis. Treg cells are highly abundant in the mouse intestinal lamina propria, particularly in the colon. Recent studies using germ-free and gnotobiotic mice have revealed that specific components of the intestinal microbiota influence the number and function of Treg cells. Substantial changes in the composition of microbiota have been associated with inflammatory bowel disease. In this review, we will discuss recent findings that associate intestinal microbiota in mice with Treg responses and with the maintenance of intestinal immune homeostasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 24, Issue 1, February 2012, Pages 50–57
نویسندگان
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