کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3391651 | 1221067 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immune homeostasis in the respiratory tract and its impact on heterologous infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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![عکس صفحه اول مقاله: Immune homeostasis in the respiratory tract and its impact on heterologous infection Immune homeostasis in the respiratory tract and its impact on heterologous infection](/preview/png/3391651.png)
چکیده انگلیسی
Innate immunity at mucosal surfaces requires additional restraint to prevent inflammation to innocuous antigens or commensal microorganisms. The threshold above which airway macrophages become activated is raised by site-specific factors including the receptors for transforming growth factor beta, interleukin 10 and CD200; the ligands for which are produced by, or expressed on, respiratory epithelium. We discuss such site-specific regulation and how this is continually altered by prior infections. Resetting of innate reactivity represents a strategy for limiting excessive inflammation, but in some may pre-dispose to secondary bacterial pneumonia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 21, Issue 3, June 2009, Pages 147–155
Journal: Seminars in Immunology - Volume 21, Issue 3, June 2009, Pages 147–155
نویسندگان
Erika Wissinger, John Goulding, Tracy Hussell,