کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391700 1221072 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Homeostatic chemokines in development, plasticity, and functional organization of the intestinal immune system
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Homeostatic chemokines in development, plasticity, and functional organization of the intestinal immune system
چکیده انگلیسی

In the past decade accumulating evidence supported the view that the immune system should be regarded as trust consisting of several branches. In this review, we will first introduce the architectural features comprising the intestinal immune system emphasising its plasticity and subsequently discuss the concepts describing its development. We then focus on the chemokine/receptor system as a key integrator managing coordinated migration of and communication among the cells mediating intestinal immunity. Thus, chemokines control development and maintain functionality of the intestinal immune system that is required to perform the unique balancing act between tolerating food, curtailing commensals activities and eliminating pathogenic infections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 20, Issue 3, June 2008, Pages 171–180
نویسندگان
, , ,