کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3392020 | 1221182 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evolution of serum and intra-graft donor-specific anti-HLA antibodies in a patient with two consecutive liver transplantations
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evolution of serum and intra-graft donor-specific anti-HLA antibodies in a patient with two consecutive liver transplantations Evolution of serum and intra-graft donor-specific anti-HLA antibodies in a patient with two consecutive liver transplantations](/preview/png/3392020.png)
چکیده انگلیسی
• Originality of this work relies in comparison of evolution with time of anti-HLA antibodies in serum and graft to try to understand graft dysfunction.
The current literature suggests that anti-HLA donor-specific antibodies (DSA) may have deleterious effects on liver grafts but there is no proof that they are directly involved in the graft lesions. We report the case of a donor HLA-sensitized patient who needed a second graft 6 months after the first transplantation owing to a progressive cholestatic disease that we could finally attribute to antibody-mediated rejection (AMR). We describe the longitudinal evolution of graft function, tissue histology, serum DSA and, for the first time, intra-graft DSA after elution from biopsies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplant Immunology - Volume 33, Issue 2, October 2015, Pages 58–62
Journal: Transplant Immunology - Volume 33, Issue 2, October 2015, Pages 58–62
نویسندگان
Martine Neau-Cransac, Brigitte Le Bail, Gwendaline Guidicelli, Jonathan Visentin, Karine Moreau, Alice Quinart, Anna Boueilh, Christophe Laurent, Jean-Luc Taupin,