کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3392204 1221202 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Feasibility of diagnosing renal allograft dysfunction by oligonucleotide array: Gene expression profile correlates with histopathology
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Feasibility of diagnosing renal allograft dysfunction by oligonucleotide array: Gene expression profile correlates with histopathology
چکیده انگلیسی

BackgroundEffective non-invasive monitoring method to tell histopathology is a big challenge in renal transplantation.MethodsWe used 70-mer long oligonucleotide array with 449 immune related genes to determine gene expression profiles of peripheral blood mononuclear cells (PBMCs) under different immune status including stable renal function (TX), acute tubular necrosis (ATN), biopsy conformed acute rejection (AR), clinical rejection with pathology of borderline changes (BL), clinical rejection without biopsy proven/presumed rejection (PR) and renal dysfunction without rejection (NR).ResultsDistinct molecular expression signatures in each group were found to correlate with histopathology. And we concluded that B cell chemokine CXCL13 and mast cell may play a role in renal allograft rejection through significant difference analysis and functional pathway analysis.ConclusionsIt provides a potential non-invasive method for monitoring renal allograft function and immune status of renal transplant recipients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplant Immunology - Volume 24, Issue 3, 15 April 2011, Pages 172–180
نویسندگان
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