کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3392479 1221222 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of tissue adaptation and graft size in immune tolerance
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The role of tissue adaptation and graft size in immune tolerance
چکیده انگلیسی

Understanding how immune tolerance is induced and maintained is critical for our approach to immune-related diseases. Ecoimmunity is a new theory that views the immune system–tissue interaction as a co-adapting predator–prey system. Ecoimmunity suggests that tissues adapt to the selective immune pressure during ontogeny and throughout life. Therefore, immune tolerance towards ‘self’ represents a symmetric balance between the propensity of the immune system to prey on ‘self’ cells, and the tissue's specific capacity to undergo phenotypic adaptations in order to avoid destructive immune interaction. According to this theory, we hypothesized that tissues of adult immune-deficient mice, which are not exposed to selective immune pressure, will not withstand immune activity and will therefore display higher susceptibility to graft rejection. To test this prediction, C57Bl/6 wild type female mice were rendered diabetic by streptozotocin and transplanted with syngeneic pancreatic islets isolated from either immune-deficient C57Bl/6 SCID or wild type females. Remarkably, recipients of islet grafts from immune-deficient syngeneic donors displayed significantly impaired glucose homeostasis compared to mice transplanted with islets of wild type donors (p < 0.001, two way repeated measures ANOVA). The severity of this impairment was correlated with islet graft size, suggesting a capacity of transplanted islets to gradually acquire a tolerogenic phenotype. These findings support the view of graft survival that is based on ‘natural selection’ of tissue cells. In addition, we describe a new experimental system for molecular characterization of self-tolerance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplant Immunology - Volume 18, Issue 2, November 2007, Pages 122–125
نویسندگان
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