کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
339428 548081 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features
چکیده انگلیسی

We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor β-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. In a 90 family subset of the Irish Study of High Density Schizophrenia Families, the PAH 232 bp microsatellite allele demonstrated significant association with the delusions factor using both QTDT (F = 8.0, p = .031) and QPDTPHASE (chi-square = 12.54, p = .028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square = 15.51, p = .030), but not QTDT (chi-square = 2.07, p = .560).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 109, Issues 1–3, April 2009, Pages 94–97
نویسندگان
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