Lactobacillus plantarum TN627 significantly reduces complications of alloxan-induced diabetes in rats

• Lactobacillus plantarum TN627 exerts remarkable antidiabetic effects.
• L. plantarum TN627 reduces blood glucose level and improves oral glucose tolerance.
• L. plantarum TN627 changes positively the lipid profiles.
• L. plantarum TN627 exerts efficient protective effects on the liver and kidney functions.

This study aimed to assess the potential of the probiotic strain Lactobacillus plantarum TN627 for preventing alloxan-induced diabetes in rats. The oral administration of this probiotic was noted to significantly improve the immunological parameters, protect the pancreatic tissues, and reduce the pancreatic and plasmatic α-amylase activities and level of plasma glucose in the treated as compared to the control group of rats. Furthermore, this probiotic treatment was observed to markedly reduce pancreatic and plasmatic lipase activities and serum triglyceride and LDL-cholesterol rates and to increase the level of HDL-Cholesterol. It also exerted efficient protective effects on the liver and kidney functions evidenced by significant decreases in serum aspartate transaminase, alanine transaminase, lactate dehydrogenase, and gamma-glutamyl transpeptidase activities, as well as creatinine and urea contents. Taken together, the findings indicate that L. plantarum TN627 exhibits attractive in vivo antidiabetic effects that may be helpful in preventing diabetic complications in adult rats.