کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
340051 | 548181 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls matched for ethnicity, diet and life style. The plasma EPUFAs levels were similar in both groups. Among the EPUFAs enriched in the brain, predominantly docosahexaenoic acid (DHA) levels were lower in RBC (p = < 0.01) whereas higher in CSF (p = < 0.01) in male > female patients. This altered DHA metabolism may provide clues for neuropathology and treatment of schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 98, Issues 1–3, January 2008, Pages 295–301
Journal: Schizophrenia Research - Volume 98, Issues 1–3, January 2008, Pages 295–301
نویسندگان
Anvita Kale, Sadhana Joshi, Nilesh Naphade, Swati Sapkale, M.S.V.K. Raju, Anilkumar Pillai, Henry Nasrallah, Sahebarao P. Mahadik,