کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
340122 548191 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Apomorphine-induced neurodegeneration in Mongolian gerbil hippocampus
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Apomorphine-induced neurodegeneration in Mongolian gerbil hippocampus
چکیده انگلیسی

Animal experiments using pharmacological agents acting on the dopaminergic system, such as apomorphine, have been used as suitable models of schizophrenia, based on the dopaminergic hypothesis of this disorder. To determine whether dopaminergic hyperactivity may produce neuropathological changes, young Mongolian gerbils were treated with apomorphine (0.45 mg/kg) and the hippocampal CA1 region was subsequently studied by transmission and scanning electron microscopy. Acute subcutaneous administration of apomorphine induced pronounced degenerative changes in hippocampal neurons, such as swollen dendrites and axons in the neuropil and swelling of synaptic endings with a decrease in the number of synaptic vesicles. In conclusion, we think that this animal model may provide important indications about a possible dopaminergic hyperactivation mechanism, that could produce pathological changes in the hippocampus similar to those encountered in psychotic patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 95, Issues 1–3, September 2007, Pages 223–227
نویسندگان
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