کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3402559 1222725 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glucoproteína P e infección por el virus de la inmunodeficiencia humana
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Glucoproteína P e infección por el virus de la inmunodeficiencia humana
چکیده انگلیسی
P-glycoprotein (PGP) is a membrane protein and product of the MDR-1 gene, which acts as an efflux pump for several drugs, such as protease inhibitors (PI) used in HIV. Numerous studies in vitro, in experimental animals, and in patients have analyzed the relationships between PGP and the pharmacokinetic and pharmacodynamic properties of antiretroviral agents, with differing conclusions. In addition, studies focusing on the impact of single nucleotide polymorphisms in the MDR-1 gene, mainly C3435T in exon 26 and G2677A/G2677T in exon 21, on antiretroviral plasma concentrations, efficacy and adverse effects, have reported varying results, which have been attributed to the influence of other polymorphisms, such as cytochrome P450.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Enfermedades Infecciosas y Microbiología Clínica - Volume 26, Issue 3, March 2008, Pages 150-159
نویسندگان
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