کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3414588 1224868 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells
چکیده انگلیسی

Regulatory T (Treg) cells are an essential cell subset for the maintenance of immune homeostasis. Treg cells are characterized by a distinct pattern of gene expression, including the upregulation of immune-suppressive genes and the silencing of inflammatory genes. The molecular mechanisms involved in the development and maintenance of Tregs have been extensively investigated. We have identified essential transcription factors NR4a and Smad2/3 in the development of thymic Tregs and induced Tregs, respectively. This article reviews the roles of transcription factors in the differentiation, maintenance, and function of Treg cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 18, Issue 6, June 2016, Pages 378–386
نویسندگان
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