کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3414670 1224881 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle
چکیده انگلیسی

Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and host cell-derived damage associated molecular patterns (DAMPs) by the pattern recognition receptors (PRRs). DNA as a molecular PAMP or DAMP is sensed directly or via specific binding proteins to instigate pro-inflammatory response. Some of these DNA binding proteins also participate in canonical DNA repair pathways and recognise damaged DNA to initiate DNA damage response. In this review we aim to capture the essence of the complex interplay between DNA damage response and the pro-inflammatory signalling through representative examples.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 16, Issue 10, October 2014, Pages 822–832
نویسندگان
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