کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3414699 | 1224883 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PCR array analysis of gene expression profiles in chronic active Epstein–Barr virus infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To determine the host cellular gene expression profiles in chronic active Epstein–Barr virus infection (CAEBV), peripheral blood samples were obtained from three patients with CAEBV and investigated using a PCR array analysis that focused on T-cell/B-cell activation. We identified six genes with expression levels that were tenfold higher in CAEBV patients compared with those in healthy controls. These results were verified by quantitative reverse transcription-PCR. We identified four highly upregulated genes, i.e., IL-10, IL-2, IFNGR1, and INHBA. These genes may be involved in inflammatory responses and cell proliferation, and they may contribute to the development and progression of CAEBV.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 16, Issue 7, July 2014, Pages 581–586
Journal: Microbes and Infection - Volume 16, Issue 7, July 2014, Pages 581–586
نویسندگان
Masanao Murakami, Yumiko Hashida, Masayuki Imajoh, Akihiko Maeda, Mikio Kamioka, Yasutaka Senda, Tetsuya Sato, Mikiya Fujieda, Hiroshi Wakiguchi, Masanori Daibata,