کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3415199 | 1224946 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Trypanosoma cruzi-specific immune responses were evaluated in a total of 88 subjects living in areas endemic of Chagas disease of Argentina by IFN-γ ELISPOT assays and immunoblotting. Positive T. cruzi antigen-induced IFN-γ responses were detected in 42% of subjects evaluated (15/26 positive by conventional serology and 22/62 seronegative subjects). Using immunoblotting, T. cruzi-specific IgG reactivity was detected in all seropositive subjects and in 11% (7/61) of subjects negative by conventional serology. Measurements of T cell responses and antibodies by immunoblotting, in conjunction with conventional serology, might enhance the capability of detection of exposure to T. cruzi in endemic areas.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 12, Issue 5, May 2010, Pages 359–363
Journal: Microbes and Infection - Volume 12, Issue 5, May 2010, Pages 359–363
نویسندگان
Gabriela C. Olivera, Maria C. Albareda, Maria G. Alvarez, Ana M. De Rissio, Laura E. Fichera, Gretchen Cooley, Pedro Yachelini, Hugo A. Hrellac, Hilda Riboldi, Susana A. Laucella, Rick L. Tarleton, Miriam Postan,