کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3415460 | 1593649 | 2009 | 9 صفحه PDF | دانلود رایگان |
Mast Cells (MCs) express toll-like receptor 2 (TLR2), a receptor known to be triggered by several major mycobacterial ligands and involved in resistance against Mycobacterium tuberculosis (MTB) infection. This study investigated whether adoptive transfer of TLR2 positive MCs (TLR2+/+) corrects the increased susceptibility of TLR2−/− mice to MTB infection. TLR2−/− mice displayed increased mycobacterial burden, diminished myeloid cell recruitment and proinflammatory cytokine production accompanied by defective granuloma formation. The reconstitution of these mice with TLR2+/+ MCs, but not TLR2−/−, confers better control of the infection, promotes the normalization of myeloid cell recruitment associated with reestablishment of the granuloma formation. In addition, adoptive transfer of TLR2+/+ MC to TLR2−/− mice resulted in regulation of the pulmonary levels of IL-β, IL-6, TNF-α, enhanced Th1 response and activated CD8+ T cell homing to the lungs. Our results suggest that activation of MCs via TLR2 is required to compensate the defect in protective immunity and inability of TLR2−/− mice to control MTB infection.
Journal: Microbes and Infection - Volume 11, Issues 8–9, July–August 2009, Pages 770–778