کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3415759 | 1224978 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polymorphism in the 3â² UTR of the IL12B gene is associated with Chagas' disease cardiomyopathy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study was to investigate the possible influence of a 3Ⲡuntranslated region (3ⲠUTR) polymorphism of the IL12B gene in susceptibility to Trypanosoma cruzi infection or in the development to cardiomyopathy in Chagas' disease (CD). We determined the IL12B 3ⲠUTR genotypes in a sample of 200 seronegative individuals and 260 serologically positive patients (130 with Chagasic cardiomyopathy and 130 asymptomatic). All individuals are from a Colombian region where T. cruzi infection is endemic. Genotyping was performed by the PCR-restriction fragment length polymorphism (RFLP) method. The overall distribution of the IL12B 3ⲠUTR alleles and genotypes in seronegative compared with seropositive individuals was not statistically significant. Interestingly, we found that the IL12B 3ⲠUTR CC genotype was significantly increased among cardiomyopathic patients when compared to asymptomatic individuals (16% versus 5%; P = 0.005; Pc = 0.015; OR = 3.39; 95% CI 1.3-9.15). In addition, we observed that the IL12B 3ⲠUTR C allele was present at significantly higher frequency in cardiomyopathic (33% versus 22%; P = 0.008; Pc = 0.016; OR = 1.69; 95% CI 1.12-2.55) as compared to asymptomatic. Our results suggest that IL12B 3ⲠUTR gene polymorphisms may influence the susceptibility to develop Chagasic cardiomyopathy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 9, Issue 9, July 2007, Pages 1049-1052
Journal: Microbes and Infection - Volume 9, Issue 9, July 2007, Pages 1049-1052
نویسندگان
German Zafra, Carlos Morillo, Javier MartÃn, Antonio González, Clara Isabel González,