کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3416326 1593696 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, molecular docking and evaluation of antifungal activity of Ni(II),Co(II) and Cu(II) complexes of porphyrin core macromolecular ligand
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Synthesis, molecular docking and evaluation of antifungal activity of Ni(II),Co(II) and Cu(II) complexes of porphyrin core macromolecular ligand
چکیده انگلیسی

Porphyrin core dendrimeric ligand (L) was synthesized by Rothemund synthetic route in which p-hydroxy benzaldehyde and pyrrole were fused together. The prepared ligand was complexed with Ni(II), Cu(II) and Co(II) ions, separately. Both the ligand and its complexes were characterized by elemental analysis and spectroscopic studies (FT-IR, UV–Vis, 1HNMR). Square planar geometries were proposed for Cu(II), Ni(II) and Co(II) ions in cobalt, Nickel and copper complexes, respectively on the basis of UV–Vis spectroscopic data. The ligand and its complex were screened on Candida albicans (ATCC 10231), Aspergillus fumigatus (ATCC 1022), Trichophyton mentagrophytes (ATCC 9533) and Pencillium marneffei by determining MICs and inhibition zones. The activity of the ligand and its complexes was found to be in the order: CuL ˃ CoL ≈ NiL ˃ L. Detection of DNA damage at the level of the individual eukaryotic cell was observed by commet assay. Molecular docking technique was used to understand the ligand–DNA interactions. From docking experiment, we conclude that copper complex interacts more strongly than rest two.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 93, April 2016, Pages 172–179
نویسندگان
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