کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3417367 1593742 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An epitope shared by cellular cytokeratin and Orientia tsutsugamushi
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
An epitope shared by cellular cytokeratin and Orientia tsutsugamushi
چکیده انگلیسی

Many microbial pathogens have epitopes shared with host cell components and these epitopes may induce transient or longer-term tissue-damaging autoantibody responses. We observed that several mouse monoclonal antibodies (MAbs) raised against Orientia tsutsugamushi were also reactive with host cells. One such antibody, MAb Rb105, cross-reacted with the cytoskeleton, as shown by immunofluorescent staining. Biochemical studies identified the cross-reacting component as a cytokeratin protein. These results identify an epitope shared by O. tsutsugamushi and the cytokeratins of host cells. In addition, antibodies cross-reactive with the cytoskeleton were detected in the sera of scrub typhus patients, suggesting that an epitope similar to that detected by MAb Rb105 may be recognized by human antibodies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 41, Issues 4–5, October–November 2006, Pages 125–132
نویسندگان
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