کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
341759 548546 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population
چکیده انگلیسی

Several lines of evidence have suggested that the metabotropic glutamate receptor 3 (GRM3) gene is a candidate susceptibility gene for schizophrenia. To our knowledge, six studies have investigated the genetic association between GRM3 and schizophrenia, although the results have been quite controversial. In the present study, we investigated the association between the GRM3 gene and schizophrenia in 402 Japanese people by analyzing 10 single nucleotide polymorphisms (SNPs), including all SNPs that showed significant results in previous studies. We observed no significant difference in allelic frequencies or genotypic distributions of the 10 SNPs between the controls and patients. A permutation test showed no significant global differences in estimated haplotype frequencies between the controls and patients. Thus, the present study provides no positive evidence of an association between the GRM3 gene and schizophrenia in the Japanese population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 88, Issues 1–3, December 2006, Pages 260–264
نویسندگان
, , , , , , , , , ,