کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3419467 1225827 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Le syndrome des antisynthétases : à propos de quatre observations et revue de la littérature
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های عفونی
پیش نمایش صفحه اول مقاله
Le syndrome des antisynthétases : à propos de quatre observations et revue de la littérature
چکیده انگلیسی
The antisynthetase syndrome (ASS) includes inflammatory myopathy (polymyositis or dermatomyositis), interstitial lung disease (ILD), arthritis, Raynaud's phenomenon, and mechanic's hands, associated with antibodies against aminoacyl-tRNA-synthetases, the most well-recognized being the anti-Jo1 antibody (anti-histidyl-tRNAsynthetase). We report four cases of antisynthetase syndrome and review the clinical characteristics and prognosis factors dominated by ILD. We report the cases of four women with a mean age of 42 years (28-62 years). The interstitial lung disease was found in four cases and was objectified by CT-scan in all cases. The pulmonary symptoms were consisted of dyspnea (one case) and respiratory distress (one case). The anti-Jo1 antibodies were present in the four patients. The myopathy was concomitant with pulmonary involvement (two cases), preceded it in 6 months (one case) and in the course of evolution and after 1 month (one case). All patients received corticosteroid treatment. The immunosuppressive treatment was necessary for two patients because of the severity of the pulmonary involvement. The outcome was favorable in two patients, partially favorable in a patient who presented pulmonary fibrosis. However, one patient died after developing brain abscesses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue de Pneumologie Clinique - Volume 68, Issue 6, December 2012, Pages 351-360
نویسندگان
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